The Symbiotic and Pathogenic Interaction group (SPI) studies diverse topics related to bacterial survival under stress conditions.

The primary focus is to uncover molecular and evolutionary mechanisms involved in antibiotic tolerance or persistence of the model bacterium Escherichia coli and pathogenic bacteria.

Additionally, we study mechanisms conferring bacterial tolerance to ethanol and survival of nitrogen-fixing rhizobia upon seed application.

To this end, a combination of molecular genetic, high-throughput genomics and transcriptomics, microscopic techniques and modeling are used. With these results, we aim at contributing to the discovery of novel antibacterials, the production of second-generation bio-ethanol and the improvement of the symbiotic interaction between rhizobia and legumes.

News flash


13 November 2019: Celien and Hanne have been nominated for the IE-net prizes. Check out their posters (in Dutch) here and here and feel free to vote!


12 November 2019: Dorien successfully defended her PhD, congratulations! We are thrilled to welcome you as a post-doc in our lab.


20 October 2019: The SPI group participated in the VIB Biotech Day. More info can be found here.


17 October 2019: Liselot published a review on persistence and heteroresistance in Molecular Cell. Congratulations! 


10 October 2019: Celien, Hanne and Sang were awarded a prestigious fellowship from FWO Vlaanderen, an extraordinary achievement!


8 October 2019: In collaboration with the VIB-BioI core, Bram has created a Compendium of Adaptive Microbial Experiments in the Lab (CAMEL Databse). Check it out here!


18 September 2019: Our new website is online! Many thanks to Sabrina from BAMdesign and her sparkling sidekick.


10 September 2019: Etthel wrote a perspective on tolerance and persistence for mBio. Nice work!


9 September 2019: Together with the Structural Biology lab of Wim Versées, we found some "Biochemical determinants of ObgE‐mediated persistence" that were published in Molecular Microbiology



Missed a SPI news flash? Older items are stored in the News archive.

Copyright 2019 by BAMdesign @ All Rights Reserved